PET plays critical role in supporting Parkinson’s Disease Research





A study conducted to measure the effectiveness of dopamine cell transplantation in Parkinson’s disease patients shows significant improvements in motor skills and brain function, according to research reported in the January issue of The Journal of Nuclear Medicine (JNM). The results of this study demonstrate that transplanted cells were viable and integrated well with the host brain tissue. Furthermore, these cells produced dopamine that helped support the brain and led to an improvement in motor symptoms. These improvements were sustained over a four-year study period.

David Eidelberg, M.D., study co-author and director of the Neuroscience Center at the Feinstein Institute for Medical Research in Manhasset, N.Y said, This study provided new insights into the time course of transplantation outcome. Comprehensive long-term clinical follow-up, together with molecular imaging, allows for a more realistic appraisal of this kind of intervention for Parkinson’s disease.

Researchers reported long-term clinical and imaging outcomes after transplantation from 33 patients who originally participated in a one-year, double-blind, placebo-controlled trial of embryonic dopaminergic cell implantation for Parkinson’s disease. Clinical improvement in motor ratings, as well as increased brain uptake of 18F-fluorodopa (18F-FDOPA)—the radiotracer that is widely used to investigate the function of dopamine grafts—was evident at one, two and four years after the transplantation surgery.

The findings reported in this study demonstrate the critical roles played by positron emission tomography (PET)—a noninvasive molecular imaging technique—in screening patients for transplantation procedures and in objectively assessing graft survival over the long term.

Yilong Ma, Ph.D., lead author of the JNM study and associate investigator at the Feinstein Institute for Medical Research said,  This work provides a valuable template for conducting imaging-based trials of cell transplantation for Parkinson’s disease and perhaps other neurodegenerative disorders. It offers guidance in the design of this type of trial, particularly with respect to the use of quantitative imaging as an adjunct to clinical assessments.

According to the National Institute of Neurological Disorder and Stroke, Parkinson’s disease belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms are tremor—or trembling in hands, arms, legs, jaw and face; rigidity—stiffness of the limbs and trunk; bradykinesia—slowness of movement; and/or postural instability—impaired balance and coordination.

Parkinson’s disease usually affects people over the age of 50. Early symptoms are subtle and occur gradually. In some people, the disease progresses more quickly than in others. Parkinson’s disease is both chronic (meaning that it persists over a long period of time) and progressive (meaning that its symptoms grow worse over time). There is presently no cure; however, a variety of medications provide dramatic relief from the symptoms. Novel surgical interventions such as cell transplantation and gene therapy are currently being investigated for patients with medically refractory symptoms.

About SNM—Advancing Molecular Imaging and Therapy

SNM is an international scientific and medical organization dedicated to raising public awareness about what molecular imaging is and how it can help provide patients with the best health care possible. SNM members specialize in molecular imaging, a vital element of today’s medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated.

SNM’s more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.snm.org .