No Symptom Awareness Leads To More Dementia Progression Risk


As per a new study, people who are not self-aware when it comes to their memory loss are more likely to experience Alzheimer’s clinical progression.

Researchers have evaluated the health data pertaining to 436 older adult participants under Alzheimer’s Disease Neuroimaging Initiative. The participants were anticipated to be cognitively normal at baseline when it came to a standardised measure and had a minimum of two years of follow-up.

The clinical progression was apparently gauged by the first instance of two continuous follow-up clinical dementia rating scale international scores of 0.5 or more. The researchers made use of two new awareness subscores when it came to heightened awareness and unawareness so as to measure the memory decline of participants. The same were assessed using a questionnaire that was given to both participants as well as their study partners.

The signs of clinical progression were witnessed in 21% of the participants across the study period. A 1-point enhancement in the unawareness subscore was related to an 84% decreased risk of progression. Besides, a 1-point dip in the subscore was associated with a 540% rise in the risk of progression. In terms of comparison, there wasn’t any prominent result found in terms of heightened awareness or traditional awareness subscores.

The inferences also offer additional proof that the informant-reported and discordant-self cognitive dip may give a key understanding to the clinicians who look after the patients who are at risk when it comes to dementia.