GHRP-6 Vs. Hexarelin- Which one is the winner in the cardiovascular wellness battle? If you are interested to know the answer, please keep reading. Without further ado, let’s begin!
In animal studies, growth hormone-releasing peptides, or GHRPs, are synthetic sequences of amino acids that trigger the release of growth hormones. Researchers have not yet figured out how they function. It has been hypothesized that they may affect both the pituitary and hypothalamus glands.
The antioxidant properties of GHRPs have been studied, and the results suggest that they have cardioprotective and cytoprotective effects through lowering inflammation. This article compares and contrasts hexapeptides, Hexarelin, and GHRP-6, focusing on their effects on growth hormone release and their work method.
What Is Hexarelin?
Hexarelin is a newly synthesized GHRP that is a near relative of GHRP-6. It is a synthetic analog of ghrelin, a peptide with 28 amino acids, and has been designed to stimulate growth hormone release. It is very similar to GHRP-6 and is thus a synthetic analog of ghrelin.
Hexarelin and GHRP-6 are structurally identical except for GHRP-6’s addition of two methyl groups. Because of its very selective mechanism of action, this peptide may be taken orally or sublingually without losing its efficacy. Because of its effect on cardiac cell survival after ischemia and nutritional restriction, it has been the subject of substantial research.
Comparatively, its biological action is more significant, and its stability is higher than that of ghrelin. It’s a peptide made up of only six amino acids, and its sequence is (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2). With a molecular weight of 887 g/mol and an empirical formula of C47H58N12O6, this substance is rather heavy for its size.
Through phospholipid-dependent protein kinase (PKC) signaling, Hexarelin causes hormone release in animal test subjects by binding to particular receptors in the pituitary and hypothalamus. It binds to and activates the cardiac receptors CD36 in a manner analogous to that of ghrelin, which stimulates the release of growth hormone from the pituitary gland.
What Is GHRP-6?
Met-enkephalin is the precursor of Growth hormone-releasing peptide-6, a first-generation synthetic hexapeptide. Consists of a series of 6 artificial D amino acids in the order (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2). This hexapeptide was discovered almost a decade ago, making it the pioneering hexapeptide to be explored in animal model research.
GHRP-6 finds its target receptors in the hypothalamus and pituitary. Research has shown that GHRP-6 receptors are widely distributed in many peripheral organs, including the heart, adrenal glands, ovaries, testes, lungs, and skeletal muscles.
The empirical formula for this peptide is C46H56N12O6, and its molecular weight is 873 g/mol.
Mechanism Of Action
Evidence from animal studies suggests that GHRP-6 acts on a receptor distinct from that of endogenous Growth Hormone-Releasing Hormone that activates ghrelin, hence increasing GH synthesis in the pituitary or brain (GHRH).
The pituitary gland, the central nervous system, the liver, and the stomach play essential roles in GHRP-6 studies.
Cardioprotective Hexarelin
Experimental evidence in mouse models demonstrates that Hexarelin shields cardiac cells from damage during cardiac arrest. The protein inhibits cardiac cell death by interacting with CD36 receptors. Increased cardiac cell survival and decreased malondialdehyde levels are two ways the peptide aids in bettering heart function (cardiac cell death marker).
Hexarelin has enhanced cardiac function in diabetic rat models by influencing how the heart’s muscle cells handle calcium and potassium. Interestingly, the research also shows that GHRP-6 is more effective than ghrelin.
By causing a shift from a sympathetic (increased blood pressure, heart rate, etc.) to a parasympathetic (normalized) nervous system response, GHRP-6 facilitates cardiac remodeling. Short-term health and results are improved, and the requirement for long-term cardiac medicine and scar tissue repair is reduced, thanks to this control.
GHRP-6 And Muscle safety
This peptide effectively protects muscle cells in general, not only the heart. Cachectic rat muscle GHRP-6 regulates calcium flow and mitochondrial dysfunction (extreme weight loss due to illness or chemotherapy). Protecting mitochondria helps keep muscle cells alive as well. Following chemotherapy, calcium ion levels are often altered, and GHRP-6 may aid in restoring standard control of these levels.
Reductions in Body Fat Measures And GHRP-6
Blood lipid levels that are too high are a physiologic disorder known as dyslipidemia. Improved glucose homeostasis and insulin sensitivity are two of the many benefits rats get with GHRP-6. Consequently, researchers may utilize it in place of current lipid medicines to treat severe dyslipidemia.
GHRP-6 Vs. Hexarelin
The effects of these peptides are almost identical in animal studies. Weight reduction, increased lean muscle mass, cardiovascular protection, speedier healing from accidents, etc., are all effects of both.
While GHRP-6 is effective in stimulating growth hormone (GH), adrenocorticotropic hormone (ACTH), cortisol, and prolactin, Hexarelin is preferred due to its ability to do so even while the subject is asleep. Hexarelin does not affect plasma glucose, luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, or insulin-like growth factor-1. In contrast to GHRP-6, it does not increase ghrelin and has a longer half-life.
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