Research has demonstrated that clinical practice guidelines (CPGs) are truly major and effective tools in the practice of delivering evidence-based medicine to achieve effectiveness of better patient outcomes and safer care. They are required to be used in all JCI accreditation programs. Yet despite its value, CPGs are not always followed by physicians due to various reasons. Keeping updated with the latest research and guidelines can prove to be a major challenge for many providers. Clinical Practice Guidelines: Closing the gap between theory and practice: a collaboration of JCI and Elsevier, examines the critical role of clinical practice guidelines in achieving safe, high-quality care for patients every time. This whitepaper describes the role and value of CPGs and addresses the barriers to implementing them. It also provides approaches to tackling challenges and highlights how technology and clinical decision support solutions can help transform research into practice.